Optimisation of peptide drug synthesis technology

- Sep 01, 2019-

Researchers in China have carried out hand synthesis of non-natural amino acids by focusing on the study of important endogenous peptides and self-designed peptide molecules in china, in order to overcome the relatively single method of chemical modification of existing polypeptide drugs and limited modification of structural units. 

In addition, non-natural amino acids can be introduced to improve the stability of peptide drugs, the use of "yin and yang" balance strategy to improve the ability of peptide drugs to permeable cerebral barrier, according to the mechanism of action, the design of new peptide drugs to reduce toxic side effects. At present, computer-aided technology can also be used to reasonably design peptide candidate drugs.