Selank is an anti-anxiety, anti-anxiety peptide-based drug developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is a heptapeptide having the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro and is a synthetic analog of human tetrapeptide tuftsin.
Selank is a synthetic analog of immunomodulatory peptide cluster proteins; therefore, it mimics many effects. It has been shown to modulate the expression of interleukin-6 (IL-6) and affect the balance of T helper cell cytokines. It has been shown to affect the concentration of monoamine neurotransmitters and induce the metabolism of serotonin. There is evidence that it may also regulate the expression of rat brain-derived neurotrophic factor (BDNF).
Selank and the related peptide drug semax have been found to inhibit enzymes involved in the degradation of enkephalins and other endogenous regulatory peptides, which may be related to their action.
Experimental and clinical studies have shown that Selank has the following pharmacological effects:
- Improve learning and memory processes
- Increased sensory attention
- Increased curiosity
- improved mental clarity
- Recovery of serotonergic and noradrenergic brain activity balance
- Anxiolytic - Inhibition of anxiety
- anti-viral activity without side effects
- Spiritual stimulants, anti-aging and enhanced mental energy
- Stabilizing mood and overall well-being
- Reversal of Angdonia
- potential recovery of catecholaminergic system function after injury caused by injury