Specifications：2mg/vial. And 5mg/vial. and 10mg/vial.
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Storage conditions: Store at 2 - 7°C. Keep tightly closed. Store in a cool dry place.
tion Molecular formula: C78h123n23o23s2
GDF-8 (Myostatin)is a member of the transforming growth factor-beta (TGF-beta) superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads to doubling of skeletal muscle mass. Myostatin-deficient mice have been used as a model for studying muscle-bone interactions, and here we review the skeletal phenotype associated with altered myostatin signaling. It is now known that myostatin is a key regulator of mesenchymal stem cell proliferation and differentiation, and mice lacking the myostatin gene show decreased body fat and a generalized increase in bone density and strength. The increase in bone density is observed in most anatomical regions, including the limbs, spine, and jaw, and myostatin inhibitors have been observed to significantly increase bone formation. Myostatin is also expressed in the early phases of fracture healing, and myostatin deficiency leads to increased fracture callus size and strength. Together, these data suggest that myostatin has direct effects on the proliferation and differentiation of osteoprogenitor cells, and that myostatin antagonists and inhibitors are likely to enhance both muscle mass and bone strength.
GDF-8(Myostatin)is known as a potent inhibitor of muscle growth and development, and myostatin is also expressed early in the fracture healing process. The purpose of this study was to test the hypothesis that a new myostatin inhibitor, a recombinant myostatin propeptide, can enhance the repair and regeneration of both muscle and bone in es of deep penetrant injury.
Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury.
Myostatin GDF -8 PropeptideMyostatin GDF -8 PropeptideGDF-8 Application
Some studies show that the lack of myostatin gives rise to impressive results in the increase of muscle mass both in humans and in animals. In bones specifically, the lack of myostatin increases its mineral density, resulting in an increase of the calcium levels of the organism. Calcium is stored in bones and it is necessary for the correct functionality of the heart, muscles, and nerves as well as for blood clotting.
While using this recombinant myostatin propeptide, it was found that collagen-rich fibrous tissue was plentiful in the injured area of the individual’s treated muscle, which has as a result the improvement of the regenerative capacity of the body.